malignant transformation
Enchondroma
Definition
Benign intramedullary cartilage lesion
Etiology
Multiple Hereditary Exostosis
AKA
Diaphyseal Aclasis / Multiple Osteochondromas
Definition
Heritable skeletal dysplasia
Epidemiology
AD with variable penetrance (96%)
Malignant Transformation
Incidence of malignant transformation much higher
- 10% overall
- 1 % / year
Chondrosarcoma (CS) > Osteosarcoma (OS)
Giant Cell Tumour of Bone
Definition
Benign lesion with a wide spectrum of behavior characterized by stromal cells and giant cells
Epidemiology
Common
- 20% of benign tumours
More common females
- F:M = 1.5:1
- most tumours M>F
Usually patient in 20's
- usually after skeletal maturity
- 3% < epiphyseal closure
Fibrous Dysplasia
Definition
Developmental hamartoma in which areas of the skeleton fail to mature normally
- remain indefinitely as immature, poorly mineralized trabeculae
Pathology
Hamartoma of bone and fibrous tissue
McCune - Albright's Syndrome
Rare triad of
1. Fibrous Dysplasia